YAP1 and breast cancer: Indeed, one of the first studies implicating YAP in cancer identified it as the protein-coding gene in a 350-kilobase amplicon found in a mouse mammary tumor [44], and YAP is also on the syntenic human amplicon (chromosome 11q22) that is amplified in a variety of cancer types [45,46,47,48,49,50,51,52,53,54,55].