In this study, we applied a proprietary NGS-based comprehensive genomic profiling assay [18] to systematically study the genomic profiles of an unselected solid cancer cohort of 1565 patients, with the purpose to uncover the distribution of activating EGFR mutations (including substitutions and small insertions and deletions) across tumor types, to further understand the genetic alterations associated with oncogenic EGFRs in an unbiased manner, and to provide further insight into optimal and personalized therapeutic strategies. This evidence concerns the gene EGFR and neoplasm.