All three contemporary P2Y12 agents were used (clopidogrel: 42%, prasugrel: 30%, ticagrelor: 29%).The primary outcome, ACM, MI, revascularization, stroke, and TIMI major bleeding at 18 months was lower in 6-month vs. 12-month DAPT (4.8% vs. 6.6%, pni = 0.004). This evidence concerns the gene P2RY12 and Stroke.