CACNA1H and familial hyperaldosteronism: Familial hyperaldosteronism type IV (FH type IV) is caused by gain-of-function mutations in Cav3.2, a T type Ca2+ channel encoded by CACNA1H. FH type IV was first identified in 2015 by exome sequencing of 40 unrelated subjects with early-onset hyperaldosteronism and hypertension (<10 years of age) [22].