For patients who carry certain prognostic biomarker mutations such as isocitrate dehydrogenase (IDH), a new GBM may show certain characteristic features, such as a large, non-enhancing mass with pial invasion, decreased blood flow, minimal edema and necrosis, and a tendency to be present in the frontal and temporal lobes [17,18]. Here, IDH2 is linked to glioblastoma.