FN1 and B-cell chronic lymphocytic leukemia: A similar interaction between fibronectin and integrin α4β1 exists within the bone and is important in the homing of chronic lymphocytic leukemia B cells to stromal cells in the bone marrow [67]; therefore, similar effects of fibroblast-derived fibronectin and HPC recruitment in pre-metastatic niche formation may occur during bone metastasis.