Whilst Shiozawa et al. [76] demonstrated that CXCR4 inhibition decreased bone marrow prostate cancer cells by inducing the mobilization of the tumor cells back into the circulation, Wang et al. [134] showed that the same treatment regime did not affect the number of prostate DTCs that homed to the bone, but instead altered the distribution. Here, CXCR4 is linked to Familial prostate cancer.