Stromal cell derived factor (SDF-1) or CXCL2 and its chemokine receptor CXCR4 can induce EMT in GBM via activation of PI3K/AKT and extracellular-signal-regulated kinase (ERK) pathways, and its inhibition suppresses EMT in glioma cell lines by upregulating E-cadherin [96]. The gene discussed is AKT1; the disease is glioblastoma.