miRNA 200 family targets ZEBs and regulates negative tumor development and EMT, whole-genome miRNA analysis of GBM shows that loss of miRNA200c expression is related with EGF receptor (EGFR) amplification and ZEB1 overexpression [152,153,154], suggesting the involvement of ZEB1 in tumor aggressiveness [155]. This evidence concerns the gene EGFR and glioblastoma.