The connective tissue growth factor (CTGF) mRNA and insulin-like growth factor binding protein 2 (IGFBP2) protein levels were elevated in exosomes of irradiated gliomas; additionally, these exosomes promote the activation of molecules involved in cell migration, such as neurotrophic tyrosine kinase receptor type 1 (TrkA), focal adhesion kinase (FAK), paxillin, and proto-oncogene tyrosine-protein kinase Src (Src), in exosome-recipient cells [171]. Here, CCN2 is linked to central nervous system cancer.