The invasive phenotype of malignant gliomas has been associated with the activation of several cell surface receptors including receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs), tumor growth factor-β receptor (TGF-β receptor), integrins, immunoglobulins, tumor necrosis factor (TNF) family, cytokine receptors and protein tyrosine phosphatase receptors [142]. Here, TNF is linked to malignant glioma.