Oncogenic NOTCH activation is not characteristic of B-ALL, but NOTCH1 and NOTCH2 mutations have been identified in other B-cell malignancies such as chronic lymphocytic leukemia (CLL), splenic marginal zone lymphoma (SMZL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL) and, rarely, follicular lymphoma (FL) [74]. Here, NOTCH2 is linked to B-cell chronic lymphocytic leukemia.