At the same time, gain-of-function mutations in the IL7R gene act as oncogenes in T-ALL and B-ALL by generally corresponding to in-frame insertions and indels in the transmembrane domain (e.g., p.L242_L243delinsLCP [49], 243InsPPCL, S185C, 246InsKCH, 241InsFSCGP, 244InsCHL, 244InsPPVCSVT [56], p.Leu242_Leu243insAsnProCys, p.Thr244_Ile245insCysProThr, p.Ile241_Thr244delinsSerAlaAsnCysGlyAla, p.Pro240_Ser246delins LeuGlnSerCys [57]). The gene discussed is IL7R; the disease is acute lymphoblastic leukemia.