PTPN11 and acute lymphoblastic leukemia: Common genomic lesions of BCR-ABL-like ALL include the B-lymphoid transcription factor genes (particularly IKZF1 deletions), somatic mutations in JAK-STAT and RAS signaling (NRAS, KRAS, PTPN11, NF1), and, less commonly, kinase alterations (FLT3, NTRK3, BLNK, TYK2, PTK2B).