Gene expression profiling, cytogenetics, and immunophenotypic analyses have been used to identify nonrandom genetic lesions in T-ALL corresponding to rearrangements involving TCR genes (TCRA/TRAC (14q11), TCRB/TRB (7q34-35), TCRG/TRG (7p15), and TCRD/TRD (14q11)) and lesions with known oncogenes [101]. The gene discussed is THRB; the disease is acute lymphoblastic leukemia.