Within B-ALL, the structural DNA rearrangements are part of the recurrent genetic abnormalities associated with this disease including hyperdiploidy, hypodiploidy, t(12;21)(p13;q22) TEL-AML1(ETV6-RUNX1), t(v;11q23) KMT2A(MLL1) rearranged, t(1;19)(q23;p13.3) E2A(TCF3)-PBX1, t(9;22)(q34;q11.2) BCR-ABL(ABL1), t(5;14)(q31;q32) IL3-IGH, iAMP21, and BCR-ABL-like [9]. This evidence concerns the gene PBX1 and acute lymphoblastic leukemia.