Besides commonly observed fusions (e.g., TCRB/TRB-LMO2, STIL/TAL1(SCL), TCRB/TRB-HOXA10, SET-NUP214(CAN)), RNA-sequencing has revealed new non-recurrent gene fusions (e.g., HOXA11-AS-MIR181A1HG, MAST3-C19orf10/MYDGF) and rearrangements (e.g., TCRA/TRAC-SOX8) in T-ALL patients, which indicates that these lesions could be a hallmark of a very poor prognosis in T-ALL [106]. Here, SET is linked to acute lymphoblastic leukemia.