MAPK1 and neuroblastoma: For example, some of them have shown that resveratrol induced activation of the mitogen-activated protein kinases, extracellular-regulated kinases (ERK1 and ERK2), in human neuroblastoma SH-SY5Y cells; others proved the anti-apoptotic effect of trans-resveratrol on paclitaxel-induced apoptosis; on the other hand, some researchers elucidated a neuroprotective effect of resveratrol against β-Amyloid (Aβ)-induced neurotoxicity and showed that resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine.