The RTS type-I or Rothmund-type includes by definition patients negative to RECQL4 mutations who present like the RTS-II ones poikiloderma, ectodermal dysplasia and growth retardation but differ in displaying the hallmark sign of bilateral juvenile cataracts: the RTS-I genetic defect is so far unknown [1]. This evidence concerns the gene RECQL4 and Rothmund-Thomson syndrome.