After we established ELISA systems to distinguish SCCA1 and SCCA2, we explored the usefulness of measuring SCCA2 in both adult and pediatric AD patients because in vitro analyses had shown that SCCA2, compared with SCCA1, is dominantly expressed by IL-4 or IL-13 in keratinocytes [24,25,76]. The gene discussed is IL4; the disease is Alzheimer disease.