IDH1 and central nervous system cancer: Although these cells present neither IDH1 mutation nor 1p19q co-deletion, two molecular markers of ODs in vivo, this does not contradict their OD origin, since it is controversial whether a stable glioma cell line with these features can be established, and, moreover, the radio-chemosensitivity of these cell models is similar to that of primary ODs [20,31,32,33].