IFIH1 and cytomegalovirus infection: A CMV infection can cause severe damage to various organs (ie, intestine, lung, central nervous system, and eye), and the damage sometimes may be fatal – especially in immunocompromised patients.[23] Considering that anti-MDA5 Ab-positive DM patients frequently develop RPILD with a poor prognosis and have a high risk of developing opportunistic infections caused by intensive immunosuppressive treatments, such infections will cause poorer prognoses for these patients.