In this study of people with and without T2DM, we found that VEGF levels in plasma were positively correlated with glycemic control indicators (FBG and HbA1c), and inflammatory parameters (Th1, Th1/Th2 ratio), while they were negatively correlated with Treg percentage; further multiple linear regression analysis revealed that HbA1c and Th1/Th2 ratio were the independent predictors of VEGF levels in plasma of T2DM patients. The gene discussed is VEGFA; the disease is type 2 diabetes mellitus.