PANK2 and cerebellar ataxia: The clinical manifestations of PKAN are generally extrapyramidal: dystonia, gait irregularity, athetosis, walking instability, limb weakness and spasms, numbness, ataxia, language disorders, slurred speech, dementia, dizziness, headache, disturbance of consciousness, coughing whereas consuming water, and eating difficulties.[4,5] The pathogenesis of PKAN is putatively initiated by inhibition of pantothenate kinase 2 synthesis reportedly due to a PANK2 mutation.