IDH2 and neoplasm: When we compared these 712 G-CIMP-low signatures at recurrence with non-tumor, normal neuronal cells and normal glial cells, we observed that the G-CIMP-high (primary and first recurrent) tumors were normal-like, contrary to what we found for G-CIMP-low recurrent tumors and grade IV IDH-wild-type (primary and recurrent) GBMs.