We previously grouped primary gliomas into two IDH-driven macro-clusters eventually leading to the identification of three IDH mutant-specific DNA methylation subtypes (Codel, G-CIMP-high, and G-CIMP-low) and three IDH wild-type-specific DNA methylation subtypes (classic-like, mesenchymal-like, and LGm6). The gene discussed is IDH2; the disease is glioma.