STAT3 and central nervous system cancer: STAT3 is known to play a role as a master regulator of mesenchymal differentiation in glioma cells (Carro et al., 2010), and, hence, this provides meaningful insights into the evolution of G-CIMP-low recurrent cells along the aberrant mesenchymal lineage transformation and unfavorable patient outcomes because these tumors can emerge as secondary GBMs.