MYC and neoplasm: Dysregulation of MYC is often achieved through the formation of large tumor-specific super-enhancers in the region surrounding the MYC gene (Chapuy et al., 2013; Fulco et al., 2016; Herranz et al., 2014; Hnisz et al., 2013; Lin et al., 2016; Liu et al., 2015; Lovén et al., 2013; Shi et al., 2013; Whyte et al., 2013; Zhang et al., 2016).