To gain insights into the potential role of DNA loop structures in gene control at the MYC locus, we generated cohesin HiChIP data for HCT-116 cells and collected published DNA interaction data for three other cancer cell types for comparison (Figure 1B; Tables S1 and S5) (Hnisz et al., 2016a; Pope et al., 2014). The gene discussed is MYC; the disease is cancer.