Previous studies have established that tumor cells acquire tumor-specific super-enhancers at various sites throughout the MYC locus (Figures 1A and S1A) (Bradner et al., 2017; Chapuy et al., 2013; Gabay et al., 2014; Gröschel et al., 2014; Herranz et al., 2014; Hnisz et al., 2013; Lin et al., 2016; Lovén et al., 2013; Parker et al., 2013; Zhang et al., 2016; Shi et al., 2013), but the mechanisms by which these diverse enhancer structures control MYC are not clear. Here, MYC is linked to neoplasm.