CTCF binding is abrogated when its sequence motif is methylated (Bell and Felsenfeld, 2000; Maurano et al., 2015), and the MYC enhancer-docking site occurs within a CpG island that is consistently hypomethylated in different tumor types as well as in different normal tissues (Figures S4A and S4B). This evidence concerns the gene CTCF and neoplasm.