FGF21 and type 2 diabetes mellitus: Soberg et al. (2017) showed that the carbohydrate preference was specific to sugary products and may also increase alcohol intake. These findings are consistent with data from animal studies showing that FGF21 signals to reward centers in the brain (Talukdar et al., 2016a, von Holstein-Rathlou et al., 2016). The human genetic studies found no detectable effect on the risk for type 2 diabetes and only nominal evidence for an effect on BMI (Soberg et al., 2017).