INS and type 2 diabetes mellitus: The associations between body composition and blood pressure have similarities to those of the Pro12Ala allele in PPARG, in which the allele associated with lower total body-fat percentage is also associated with adverse metabolic effects, although there are clear effects of the PPARG allele with type 2 diabetes and insulin sensitivity in addition to body composition (Altshuler et al., 2000, Scott et al., 2012).