Some studies have linked FGF21’s function in adipocytes to those of PPARG (Wei et al., 2012), a transcription factor critical for adipogenesis and mutations that cause a form of lipodystrophy characterized by greatly reduced subcutaneous body fat, insulin resistance, high circulating triglyceride levels, and higher blood pressure (Savage et al., 2003). This evidence concerns the gene INS and lipodystrophy.