Some studies have linked FGF21’s function in adipocytes to those of PPARG (Wei et al., 2012), a transcription factor critical for adipogenesis and mutations that cause a form of lipodystrophy characterized by greatly reduced subcutaneous body fat, insulin resistance, high circulating triglyceride levels, and higher blood pressure (Savage et al., 2003). The gene discussed is PPARG; the disease is lipodystrophy.