Previous studies have shown that many inflammatory factors, such as NF-κB, MCP-1, TNF-α, C reactive protein (CRP), IL-6, etc., not only take part in the dys-regulation of pancreatic hormone secretion and IR, but also in the development of the chronic complications of diabetes, such as its microvascular and macrovascular complications (12). Here, CCL2 is linked to diabetes mellitus.