TNF and meningitis: CSF levels of IL-8, IL-12p40,IL-17A, TNF-α, INF-γ and sera TNF-α were significantly higher among survivors, whichindicates that this progressive shift in cytokine expression favouring a Th1 pattern iscrucial in controlling cryptococcal infection and would be a prognostic marker incryptococcal meningitis (Mora et al. 2015, Mora et al. 2017).