Previous research found that Tg animals display poor spatial learning in the Barnes maze task compared to their wild-type littermates in a variety of AD mouse models, including TgCRND8 [12], 3xTg [13], APPswe/PS1ΔE9 [14,15] as well as the APP21 and APP+PS1 rats [9]. The gene discussed is APP; the disease is Alzheimer disease.