Failure of fat cell formation in the subcutaneous fat compartment as body fat increases, might lead to storage of fat in tissues such as visceral adipose tissue, pancreas, muscle and liver.[39] This excess storage might contribute to the unfavourable distribution of abdominal fat and hepatic steatosis, as well as impaired insulin action resulting in insulin resistance, glucose intolerance and diabetes.[40]. Here, INS is linked to diabetes mellitus.