VASH2 and diabetes mellitus: Despite no difference in increased KW/BW ratio and urine volume between diabetic WT and VASH2-deficient mice (Fig 1B and 1C), elevated Ccr level induced by diabetes in WT mice was significantly reduced in VASH2-deficient mice (Fig 1D), suggesting the potential improvement in diabetes-induced glomerular hyperfiltration with VASH2 deletion.