The dysfunctional stressed placenta releases excess levels of anti-angiogenic factors, specifically soluble fms-like tyrosine kinase 1 (sFLT) [8, 9] and soluble endoglin (sENG) [10, 11] into the maternal circulation, where they injure the maternal vasculature causing widespread endothelial dysfunction and multi-system maternal organ injury [3, 4, 12]. The gene discussed is ENG; the disease is endothelial dysfunction.