As shown in Figure 2, renal mRNA expression of Sirt1, Prkaa2 (encoding for AMPKα2), Prkab2 (encoding for AMPKβ2), Pparg (encoding for PPARγ), and Ppargc1a (encoding for PGC-1α) in ND/HS and HF/HS rats were lower, while Prkag2 (encoding for AMPKγ2) were higher than those in ND/ND rats. The gene discussed is PRKAB2; the disease is hydrops fetalis.