The beneficial effects of maternal melatonin therapy protect offspring against HF/HS-induced hypertension, including increased mRNA expression of Sirt1, Sirt4, Prkaa2, Prkab2, Pparg, Ppargc1a, and Nrf2, increased protein levels of AMPKα2, PGC-1α, mTOR, and phosphorylated mTOR, decreased plasma ADMA and SDMA levels, and increased the l-arginine-to-ADMA ratio. The gene discussed is SIRT4; the disease is Hypertension.