TGFB1 and mesothelioma: Because MEG3 has been found to modulate TGF-β activity and it has an heterogeneous expression, it would be interesting to investigate whether its expression plays a role in the EMT signature that we observed in the mesothelioma tumors developing in asbestos-exposed mice [17] and also if it contributes to mesothelioma’s so-called transitional state [62].