Here, we take the opportunity of our recent study in asbestos-exposed C57Bl/6J Nf2+/− mice [17], to identify lncRNAs and miRNAs associated with tumor development and scrutinize their expression and heterogeneity in human mesothelioma and human mesothelioma TCGA RNAome. This evidence concerns the gene NF2 and mesothelioma.