Intracellular tau aggregates are a common finding in a number of neurodegenerative disorders, collectively referred to as tauopathies, generally associated with synaptic loss and neuronal death, including AD, frontotemporal lobar degeneration (FTLD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick’s disease [10]. The gene discussed is MAPT; the disease is Alzheimer disease.