A randomized, double-blind, placebo-controlled clinical trial detected beneficial effects in metabolic parameters, such as body mass index (BMI), fat mass, waist circumference (WC), and area under the curve of insulin and total insulin secretion after supplementation with resveratrol 500 mg three times per day for 90 days in individuals with MetS (n = 24) [65]. This evidence concerns the gene INS and metabolic syndrome.