INS and metabolic dysfunction-associated steatotic liver disease: The pathogenesis of NAFLD are not completely understood and due to the fact it seems to be multi-factorial [37,38], some therapeutic strategies are used to treat patients with NAFLD and the most common pharmacological approaches include insulin-sensitizers like thiazolidinediones, such as pioglitazone [39], and lipid-lowering drugs, pentoxifylline and angiotensin receptor blockers [40,41].