PLA2G4A and colonic neoplasm: Also, curcumin was able to modulate arachidonic acid metabolism and its metabolites, blocking cytosolic phospholipase A2 (cPLA2), decreasing COX-2, and inhibiting catalytic activity of 5-lypoxigenase (5-LOX) in HT-29 human cells, a type of human colon cancer cell [107].