Consumption of a LFHCC diet supplemented with 1.24 g/day of long-chain n-3 PUFA (1.4 eicosapentaenoic acid:1 proportion of docosahexaenoic acid) for 12 weeks improved systemic insulin sensitivity compared to a standard diet, evidenced by decreased plasma insulin, a homeostasis model assessment of insulin resistance (HOMA-IR), and nonsterified fatty acid (NEFA) concentration in subcutaneous white adipose tissue (WAT) [188]. The gene discussed is INS; the disease is Insulin resistance.