This study confirmed the role of the JAK2 haplotypeGGCC_46/1 and TERT SNPs as germline factors predisposing to MPN but also identified significant associations between the occurrence of polymorphisms near SH2B3, TET2, ATM, CHEK2, PINT, and GFI1B genes and JAK2 V617F clonal hematopoiesis and/or MPN development (Figure 1) [42]. Here, SH2B3 is linked to myeloproliferative neoplasm.