JAK2 and myeloproliferative disorder: To investigate the possible interplay between somatically acquired gene mutations and inherited genetic variations in patients with myeloproliferative neoplasms (MPNs), Pardanani et al. in 2008 studied the role of single nucleotide polymorphisms (SNPs) within four candidate genes involved in the JAK-Signal transducer and activator of transcription (STAT) signaling pathway, including receptors for erythropoietin (EPOR), thrombopoietin (MPL), granulocyte colony stimulating factor (GCSFR), and JAK2 [6].