PTEN and neoplasm: Essentially, the action of intracellular IL-37b on the expression of various protein tyrosine phosphatase molecules was proffered as the probable mechanism of IL-37 mediated suppression of signal pathways and metastatic capacity of the tumor cell lines studied seeing as the inhibitory actions of IL-37b on tumor cell signaling pathways and metastasis were abolished upon incubation with pervanadate (a tyrosine phosphatase inhibitor).