A study investigating the behavior of IL-37 during the course and clinical spectrum of leprotic syndromes (viz lepromatous leprosy, tuberculoid leprosy and their immunologically erratic borderline forms) revealed the ingenuity in the response of IL-37 to varying leprotic syndromes mediated through its action on macrophages, lymphocytes, endothelial cells as well as keratinocytes. This evidence concerns the gene IL37 and lepromatous leprosy.