Clinical scores and histological indices in IL-37 expressing IL-37tg mice treated with dextran sulphate sodium (a colitis-inducing agent) were observed to be significantly reduced in comparison to IL-37 deficient controls, albeit transfection of bone marrow cells from hIL-37tg mice to wild-type age and sex matched litter mates resulted in protection from dextran sulphate sodium (DSS) induced colitis [91]. This evidence concerns the gene IL37 and colitis.