Contrarily, cytokine responses in lepromatous leprosy are mediated by the inflammation-mitigating cytokines (IL-4, IL-10 and a member of the leukocyte immunoglobulin-like subfamily of receptors dubbed LILRA-2) which inhibit TLR2/1 induce pro-inflammatory cytokine response and promote IL-10 release [111]. This evidence concerns the gene IL10 and lepromatous leprosy.