The suppressive capacity of varying concentrations of IL-35 on VEGF/Ang2 pro-angiogenic pathway (translated in terms of decreased endothelial cell adhesion, migration and tube formation) was demonstrated in in vitro cultures of human umbilical vein endothelial cells (HUVECs) and an ex vivo RA synovial tissue explant set up [41]. This evidence concerns the gene VEGFA and rheumatoid arthritis.