HTT and Huntington disease: Huntington’s disease is characterized by an expansion of cytosine-adenine-guanine/glutamine repeats; a potential therapeutic target may lie in the use of CRISPR/Cas9 to silence the mutant form of the huntingtin gene (mHtt) [152].Yang et al. (2017) demonstrated successful CRISPR/Cas9 suppression of mHtt in mouse striatal neuronal cells which resulted in the alleviation of motor impairments and neurotoxicity [152].