Holzer et al. [10] found that serum levels of ECD/ /HER-2 in 27 patients aged 10-61 years with high-grade osteosarcoma, were no higher than in the control group (2.71 ng/ml in osteosarcoma vs 3.10 ng/ml in healthy individuals and 3.85 ng/ml in long-term survivors). Here, ERBB2 is linked to osteosarcoma.