HMGB1 and neoplasm: It has been proposed that inflammation can be promoted by endogenous mediators through Toll‐like receptors (TLRs) to enhance tumor progression and metastasis.10 Many studies have shown a correlation between TLR signaling and tumor progression and metastasis; endogenous mediators, including HMGB1 (high mobility group box 1), have been implicated in the triggering of tumor‐associated inflammation.