Molecular classification shows that MM is a highly heterogeneous PC population with several different cytogenetically distinct PC malignancies, including gain(1q), del(1p), del(17p), del(13), RAS mutations, and secondary translocations involving Myc – all of which can influence disease course, response to therapy, and prognosis (Rajkumar, 2016). This evidence concerns the gene MYC and pachyonychia congenita.