IFNA1 and Hutchinson-Gilford progeria syndrome: We recently found that replication stress in HGPS patient-derived fibroblasts is accompanied by accumulation of chromatin at the cytoplasm, upregulation of cytosolic sensors of nucleic acids -cGAS, STING, RIG-I, MDA5, and OASs-, and robust activation of a cell intrinsic interferon (IFN)-like response [114].