SLC12A3 and Hyponatremia: That there may be non-NCC effects of thiazides contributing to TIH may be argued from the absence of significant hyponatremia in Gitelman syndrome [8] or Gitelman-mimic animals carrying a loss of function mutation in the NCC regulator Ste20 Proline-Alanine-rich Kinase (SPAK) [24].