TRGV9 and Hyponatremia: In support of this approach, an observational study of thiazide -associated hyponatremia found that progressively more aggressive strategies to elevate sodium in addition to thiazide cessation (including fluid restriction, parenteral infusion of normo- or hyper-tonic saline and the use of V2 antagonists such as tolvaptan) were found to be associated with increased probability of overly rapid correction of serum sodium [25].