Th2 transcription factor (GATA-3) was statistically significantly higher in the CRScNP group than in the CRSsNP and control groups (p < 0.001); whereas, Treg transcription factor (FOXP3) was statistically significantly lower in the CRScNP group than in the CRSsNP and control groups (p < 0.001). This evidence concerns the gene FOXP3 and chronic rhinosinusitis without nasal polyps.