PBMC flow cytometry detected a monoclonal B‐cell population (more than 80% of total B‐cell content) with CD19+/κ+/CD5+/CD23+/CD20+/CD43+/CD38− immunophenotype typical for CLL 3 and a small lymphocyte population (0.013% of total peripheral blood leukocytes) with CD19+/CD11c+/CD103+/LAIR‐1+/CD25+ immunophenotype typical for HCL 2. This evidence concerns the gene CD19 and B-cell chronic lymphocytic leukemia.