Since these first findings, the idea that Mecp2 expression was only neuronal has evolved, as Mecp2 was reported in non-neuronal central nervous system (CNS) cells, including astrocytes, microglia, and oligodendrocytes, and cell-specificMecp2 deletion in these cell subtypes appears to contribute to RTT neuropathology10,11. Here, MECP2 is linked to Rett syndrome.