More indications of the early involvement of the oxidative stress in AD pathogenesis stem from the data showing that markers of oxidative stress in the APP23 mice, carrying APP KM670/671NL mutation, and triple transgenic mice, harboring APP KM670/671NL, PS1 M146 V, and Tau P301L mutations, are present relatively early, before the formation of amyloid deposits [86, 87]. The gene discussed is PSEN1; the disease is Alzheimer disease.