In conclusion, we found that several important mechanisms are involved in the protective actions of DMF on the kidneys of offspring exposed to prenatal DEX and on a postnatal HF diet, including the reduction of oxidative stress, restoration of an ADMA-related NO/ROS imbalance, SEH inhibition, mediation of the PPAR signaling pathway, and induction of autophagy. The gene discussed is PPARA; the disease is hydrops fetalis.