EPHX2 and hypertensive disorder: The key findings of our study can be summarized as follows: (1) a postnatal HF diet exacerbates prenatal DEX-induced hypertension in adult male offspring; (2) combined DEX exposure and HF diet-induced hypertension relates to elevated plasma ADMA concentration, oxidative stress, and increased SEH protein levels in the kidney; (3) DMF treatment prevented DEX + HF-induced hypertension, which combined with increased renal Nrf2 gene expression, decreased plasma ADMA levels and renal protein levels of SEH, reduced oxidative stress, and activated nutrient-sensing signaling pathways and autophagy.