CAT and liver dysplastic nodule: Thirdly, CAT activity was analyzed, and it was found that the activity of CAT was decreased in glomeruli in DN model compared to control group (P < 0.05), but low-dose HACE, high-dose HACE, or positive drug benazepril only has trend to increase the activity of CAT; meanwhile importantly it was found that in serum high-dose HACE treatment increased the CAT activity which was even higher than control group (Figure 3(c)); therefore HACE treatment increased the systemic CAT activity to scavenge reactive oxygen species.