Secondly, SOD activity was analyzed; it was found that the activity of SOD in DN group was similar to control treatment group in either serum or glomeruli, indicating that the SOD activity was not decreased in DN model, but low-dose HACE, high-dose HACE, or positive drug benazepril treatment could improve the activity of SOD in glomeruli (P < 0.01, Figure 3(b)); therefore HACE and benazepril could regulate the SOD activity to clean glomerulus reactive oxygen species. This evidence concerns the gene SOD1 and liver dysplastic nodule.