FN1 and liver dysplastic nodule: Meanwhile it was reported that renal extracellular matrix (ECM) agglomeration was one of pathological characters of DN [29], and this study found that HACE treatment could inhibit the ECM accumulation and decreased the expression of fibronectin and type IV collagen, which were the components of ECM; therefore HACE treatment could inhibit renal pathological alteration at the DN stage.