Benazepril has been considered as a classic treatment drug for DN, which showed outstanding improvement of DN by decreasing the level of urinary albumin, promoting creatinine clearance, and reducing the pathological damage of the renal tissues closely related to reducing the expression of TGF-β1 and Nephrin [37–39], and this study confirmed that benazepril could decrease the level of albuminuria and total cholesterol and decrease the ECM accumulation in DN rats, which was consistent with previous study [25]. The gene discussed is NPHS1; the disease is liver dysplastic nodule.