ALB and liver dysplastic nodule: Among the indicators, blood urea nitrogen and creatinine were not affected by streptozotocin injection compared to control group; however, albuminuria, which was the protein albumin abnormally present in the urine, was significantly elevated in the diabetic model group compared with the control group (Table 1), which further indicated that the diabetic rats had suffered from renal dysfunction, and the streptozotocin-induced DN model had been successfully established.