As expected, the level of CD4+ and CD8+ T cell activation was significantly higher in AHIs and subsequently chronic HIV-1 infection stage (CHIs) compared with HDs (all p < 0.001, Figures 1A,B); however, no significant differences were found between AHIs and CHIs in CD4+ T cell immune activation (Figure 1A). This evidence concerns the gene CD8A and HIV-1 infection.