These cardioprotective effects of BK during hypertension and other clinical and experimental conditions, such as cardiac failure, ischemia, myocardial infarction, and pulmonary hypertension are believed to be B2R-mediated (Heitsch, 2003; Veeravalli and Akula, 2004; Marketou et al., 2010; Sharma and Al-Banoon, 2012; Potier et al., 2013). Here, BDKRB2 is linked to hypertensive disorder.