ACP5 and hydrops fetalis: Moreover, the number of TRAP-positive osteoclasts, which indicate the severity of bone resorption, was higher in the vehicle-treated ACLT group (27.67 ± 12.14/mm2) than Sham group (9.00 ± 4.19/mm2) and this effect was abrogated by HF to a level of 17.00 ± 7.48/mm2 (Figures 4B,F).