Indeed, many patients with Noonan Syndrome, of whom 50% typically harbor PTPN11 gene mutation (Tartaglia et al., 2002; Zenker et al., 2004), were identified with ocular abnormalities including fundal changes (Marin et al., 2012), optic disk excavation, enhanced cup to disk ratio and myopia, symptoms which are associated with higher risk of glaucoma and retinal degeneration (Whitmore, 1992; Marin et al., 2012; Lee and Sakhalkar, 2014). Here, PTPN11 is linked to glaucoma.