Several cytokines and growth factors like IL-6 or epidermal growth factor (EGF) family members, as well as hepatocyte growth factor (HGF)contribute to the phosphorylation of STAT3, then the active STAT3 interacts with its target gene to prevent apoptosis [16] and stimulates transcription of key cancer genes linked with cell cycle [17]. This evidence concerns the gene HGF and cancer.