In this context, we found that both Tmprss6−/−mice, which display a marked hypoferremic phenotype due to inadequate hepcidin upregulation, and iron-treated Tmprss6−/−mice, which are no longer hypoferremic but still preserve high hepcidin levels, were protected against the development of hepatic steatosis. Here, TMPRSS6 is linked to Hepatic steatosis.