Although p38 inhibitors represent one of the most heralded form of therapies for the treatment of inflammation in recent times, clinical trials with a range of unrelated pharmacological p38 inhibitors for the treatment of rheumatoid arthritis and other chronic inflammatory conditions have shown poor clinical outcomes with transient immunosuppressive effects, associated with increased risk of severe infections, liver/brain/skin toxicity and other adverse effects8,23,24. This evidence concerns the gene MAPK14 and rheumatoid arthritis.