Using a bioinformatics approach, we identified four genes, namely CXCL12, TLR2, RALB and CCR5 that showed a strong association with CXCR4. We additionally found that expression of CXCR4 and functionally associated genes were altered in multiple neurodegenerative diseases and associated with hippocampal tau pathology in transgenic mouse models. This evidence concerns the gene CXCL12 and neurodegenerative disease.